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The psychiatric drug lithium increases DNA damage and decreases cell survival in MCF-7 and MDA-MB-231 breast cancer cell lines expos ed to ionizing radiation

Nevertheless, the discovery of an extra-hepatic IGF-I production in the following years[18, 45], made it necessary to spand the conception of the GH/IGF-I axis, being well accepted nowadays that pituitary GH is able to induce IGF-I synthesis in both liver (~75%) and other tissues[23, 46, 47], which subsequently, is able to act in an endocrine/paracrine/autocrine manner

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Additionally, hormonal variations, particularly fluctuations in estrogen levels, have been shown to affect ligament laxity and strength, further contributing to the higher incidence of ACL injuries in females