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Ralph Carmel, one of the leading researchers on vitamin B12, published a study in 1988 with several subjects analyzed, suggesting a relationship between higher amounts of accumulated analogues and a greater risk of neurological symptoms, which could explain why some patients did not experience neurological symptoms (at least at the time) but did experience anemia

Disclosure of interest: Nothing to disclose Poster session I - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.01 - DIAGNOSIS/INVESTIGATION OF STROKE ETIOLOGY P355 - ESOC25-189 VESSEL WALL ENHANCEMENT IN TERMINAL OF INTERNAL CAROTID ARTERY WAS DECREASED AFTER DIRECT BYPASS SURGERY FOR MOYAMOYA DISEASE Daizo Ishii 1 , Takeshi Hara 1 , Masashi Kuwabara 1 , Hiroshi Kondo 1 , Shinji Kume 2 , Nobutaka Horie 1 1 Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, 2 Hiroshima University Hospital, Hiroshima, Japan Background and Aims: Intracranial vessel wall enhancement (VWE) on MR imaging is associated with progression and poor outcome in moyamoya disease (MMD)

Research has shown that Vitamin B12 has neuroprotective qualities that may help in safeguarding cognitive function