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Glucose-6-phosphate dehydrogenase (G6PD), the rate limiting enzyme of the PPP, and its regulator protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P) are increased in MM patients ( Figure 1 When MM cells become resistant to BTZ, glycolysis ( Figure 1B ) is characterized by higher glucose uptake and lactate secretion ( in vivo , increases the expression of several glycolytic enzymes ( 2.2 Mitochondrial energy metabolism and associated pathways Pyruvate can be converted to acetyl-CoA and further oxidized in the mitochondrial tricarboxylic acid (TCA) cycle to generate reducing equivalents, which in turn are used for OXPHOS to produce ATP ( OXPHOS has been described as an important energy source for MM ( Figure 1A )

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Metabolomics reveals metabolic targets and biphasic responses in breast cancer cells treated by curcumin alone and in association with docetaxel

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