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Description

This finding revealed a function of ORF45 in targeting cytoplasmic membrane vesicles (likely trans -Golgi network or derived vesicles), facilitating the maturation and release of virion particles

Depigmentation of SNpc results from the absence of these neurons, which normally contain modest levels of melanin (Lees, 2012)

Data availability Availability of data and material: All relevant data are within the paper

These iPSCs offer new opportunities for disease modeling (Silva and Haggarty, 2020), environmental toxins (Fan et al., 2022), genetic risk factors (Su et al., 2021) on human neural cell types, which would otherwise be inaccessible