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GR is stimulated by melatonin and is reportedly irreversibly inhibited by a number of oxygen radical generating systems

While serotonins exact role in depression is still being debated, low serotonin levels have traditionally been linked to symptoms such as sadness, low energy, and irritability all of which are often seen in people with major depressive disorder

This helps to reduce the risk of mislabeling or underdosing

Given the dominant contribution of oxidative stress to mitochondrial dysfunction in AP, mitochondria-targeted antioxidants have also been investigated as a means to protect mitochondriaorganelle crosstalk