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Side Effects, Tolerance, and When to Pause and Reassess Side effects from B12 itself are uncommon, but any supplement can create practical issues: food aversion if mixed into meals, stress if administration becomes a daily battle, or confusion if multiple products overlap

3.3 Effective in vivo depletion of CD38+ lymphocytes by Daratumumab Daratumumab is a depleting antibody known to eliminate CD38-expressing B cells ( Figure 2A ) ( Supplementary Figure 2 ) ( Supplementary Figure 2 ), which may explain the compromised humoral anti-viral response by the patient ( Supplementary Figure 1 )

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