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Bailey LC, Orosz ST

10.1016/j.freeradbiomed.2017.03.011 86 LiY.ChenL.ZhengD.LiuJ

The polyol pathway, where excess glucose is converted to sorbitol and fructose by the enzyme aldose reductase, further exacerbates oxidative stress by depleting NADPH, a crucial cofactor for the regeneration of reduced glutathione (GSH) [180]