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hence, it controls genes that contain ARE, electrophilic-conjugating enzymes, ubiquitin/proteasomes, and heat-shock proteins, in response to reactive oxygen species [67]

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A study suggested that in GCH1-deficient mice, BH4 could still accumulate with age, which was associated with the production of BH4 by specific gut microbiota, such as intestinal Actinobacteria [118]