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As kidney function declines, mortality and comorbidities, particularly cardiovascular complications, rise steadily (1)

TGA Medical Device Definition: A medical device is defined as any instrument, apparatus, implement, machine, appliance, implant, software, material or other similar or related device (including any diagnostic product for in vitro use) that is intended by the manufacturer to be used, alone or in combination, for human beings for the specific purpose of one or more of the following: diagnosis, prevention, monitoring, treatment or alleviation of disease

Red dots indicate positive associations between pathways and cellular functions, while blue dots represent negative associations