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Abnormal coagulation: the role of microclots and inflammagens in circulation that cause pathological clotting It has been hypothesised that hypercoagulation plays a significant role in ME/CFS (349351), but there are still discrepancies between studies (352)

Moreover, exposing mice to a low dose which reflects a typical American diet (0.01 mg/kg/day), caused gut microbiota alterations across two generations-consistent with earlier findings, Akkermansia muciniphila was depleted, while ParaBacteroides distasonis and Christensenellaceae were elevated in the second generation (Barnett et al., 2024)

So if you see elevated homocysteine, you can suspect either B12 or folate deficiency

For example, 2859% of patients with FMS that develop IBS, and 3277% of patients diagnosed with the diagnosis of IBS develop FMS during the course of their illness, with a relative risk increase of approximately 1.54-fold