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6 The stability of the model results has also been demonstrated by both types of sensitivity analysis performed, suggesting that these findings are likely to be applicable to other health-care settings and systems outside Italyprovided that there are no major differences in the ICU patient population, and/or the organisation and costs of the ICU or more generally in tertiary care

Previous studies have demonstrated that FUS-induced BBB opening may trigger CNS immune-regulation to facilitate A clearance 7,8 and animal behavioral functions can be restored 6,7

The structure of the molecule is recognisable by its glutamic acid, cysteine and glycine residues (Fig

This means that individuals on testosterone replacement therapy may require dose adjustments as they lose weight, and regular hormone monitoring is advisable