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In secondary prevention trials, one goal is to modulate the metabolism of ingested aflatoxin to enhance detoxification processes, thereby reducing internal dose and subsequent risk Ochratoxin A (OTA) Ochratoxins are the first major group of mycotoxins identified after the discovery of the aflatoxins

This ARE element is important for basal promoter activity as well as TNF-mediated induction of rat GCLM (Yang et al., 2005)