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The anti-atrophy mechanism of PCHP involved maintaining protein metabolism homeostasis in the gastrocnemius muscle through the IL-6/signal transducer and activator of transcription 3 (STAT3)/cathepsin L (CTSL) and Diacylglycerol kinase (DGK)/the forkhead box O-class (FoxO)/Atrogin1 signaling axis, mediating the ubiquitin-proteasome and autophagy-lysosome systems, and downregulating the accumulation of ceramide via sphingomyelin phosphodiesterase 2 ( 5.1.7 Anti-obesity PCHP could markedly reverse insulin resistance as indicated by a reduction in obesity markers, enhanced leptin and fasting blood glucose levels, and improvements in serum lipid profiles

Furthermore, research indicates that it may be involved in thermogenic processes within specific tissues, making it an area of interest for scientists investigating energy expenditure

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