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doi:10.1016/j.expneurol.2016.06.005

Figure 4 5,10-methylene-THF can be reduced by MTHFR into 5-methyl-THF, that enters methyl cycle where the one-carbon group of 5-methyl-THF is utilized by methionine synthase in the conversion of homocysteine (Hcy) to methionine