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5 Department of Dermatology, Pediatric Dermatology and Oncology, Laboratory of Autoinflammatory, Genetic and Rare Skin Disorders, Medical University of Lodz, Lodz, Poland Correspondence: Aleksandra Lesiak, Department of Dermatology, Pediatric Dermatology and Oncology, Laboratory of Autoinflammatory, Genetic and Rare Skin Disorders, Medical University of Lodz, 16 Pankiewicza Street, Lodz, Poland, 91-738, Email [email protected] Abstract: This comprehensive review explores the pivotal roles of glycation and oxidative stress in the aging process of the skin, emphasizing their targeted therapeutic applications in aesthetic and regenerative medicine, as well as anti-aging interventions

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232,245,246 However, these treatment options do not reverse chronic, progressive, age-related atrophy of the genitourinary tissues and are generally only to provide relief from dryness