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For Figure 1B, we would filtered the SNPs of acute lymphocytic leukemia (30), Crohn s disease (31), rheumatoid disease (32), asthma (33), supplements of vitamin B complex (34), smoking (35), and ulcerative colitis (36), which were reported to have a potential impact on the antioxidant biomarkers

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196 Although the mutation frequency of E3 ubiquitin ligase is lower than that of other WNT inhibitors, mutations of RNF43 (which mediates ubiquitin degradation of Frizzled) are still detected in the adenoma tissues of patients with GC, 218 early-onset metastatic CRC, 219 and Lynch syndrome