Funding This work was supported by the Postdoctoral Innovation Practice Base of the First Affiliated Hospital of Nanchang University (grant 338937), the Jiangxi Provincial Young Talents Project (grant 20204BCJ23016), the National Natural Science Foundation of China (grants 82202869, 82260491, 82160459, 82160469,82360584), the Jiangxi Province Double Thousand Program (grant jxsq2023201108), Key Projects of Jiangxi Province (grant 20232ACB206044), the Science and Technology Department of Jiangxi Province (grant 20202BABL216050), and the Jiangxi Provincial Natural Science Foundation (grant 20232BAB216087 and 20224BAB216008)
Immune System Enhancement and Immunosenescence Epithalon demonstrates significant immunomodulatory effects, particularly in reversing age-related immune dysfunction and enhancing thymic function
Nucleocytoplasmic transport: the last 200 nanometers
Physicochemical factors: 1) Drug solubility & dissolution rate 2) Particle Size and Effective Surface Area of the Drug 3) Polymorphism and Amorphism 4) Hydrates/Solvates (Pseudopolymorphism) 5) Salt form of the drug 6) Drug pKa and Lipophilicity and GI pHpH Partition Hypothesis 7) pKa of drug & gastrointestinal pH hypothesis 8) Drug stability PHYSICOCHEMICAL FACTORS AFFECTING DRUG ABSORPTION 1) Drug solubility & dissolution rate 2) Particle Size and Effective Surface Area of the Drug 3) Polymorphism and Amorphism 4) Hydrates/Solvates (Pseudopolymorphism) 5) Salt form of the drug 6) Drug pKa and Lipophilicity and GI pHpH Partition Hypothesis 7) pKa of drug & gastrointestinal pH hypothesis 8) Drug stability Consider the events that occur following oral administration of a solid dosage form as shown in Fig
