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Care 16 , 421427 (2012)

The cellular response to external factors amplifies the initial biochemical reactions, building up effects on metabolite networks within time intervals ranging from seconds to hours

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The mitochondria, peroxisomes, endoplasmic reticulum, endothelial cells, neutrophils, macrophages, xanthine oxidoreductase and myeloperoxidase are endogenous source of ROS generation [18,19,20]