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9 During AOM-induced HE, the upregulation of MMP9 has been shown to disrupt tight junction expression, and pharmacological inhibition of MMP9 restores tight junction protein expression to near control levels

If a polyvalent acid is being measured, and multiple endpoints are obtained, then enter PK2 and PK3 in the formula to calculate the respective second and third stage dissociation constants

Although these mechanisms are well-established in hepatic, pulmonary and skin fibrosis, data from small and large intestine is scarce

As part of metabolic tracking, glucose levels, insulin sensitivity markers, and changes in body weight are checked on a daily basis