fsp1 is a glutathione-independent ferroptosis suppressor

fsp1 is a glutathione-independent ferroptosis suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis Identification of structurally diverse FSP1

Name: fsp1 is a glutathione-independent ferroptosis suppressor Protein 1 (FSP1) and Coenzyme Q10 Cooperatively Suppress Ferroptosis Identification of structurally diverse FSP1
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Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis ScienceDirect Proposed model for the catalytic and anti ferroptotic mechanism of Download Scientific Diagram Oncology Reports The suppression of FSP1 expression via NRF2 promotes ferroptosis induced by reactive oxygen species in vascular smooth muscle cells ScienceDirect

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Description

Oxidation alters the peptide structure and reduces receptor binding affinity

Unlike patient-specific neoantigens, which require individualized immunotherapeutic development 1,2,3 , commonly mutated oncoprotein-derived epitopes presented on class I major histocompatibility complex (MHC) molecules provide an opportunity to target cancer-specific antigens shared across patient populations 4,5