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This suggests that while non canonical NF-B signaling is important for the initiation of Th cell differentiation for certain subsets (such as Th17), a shift toward non-canonical signaling may divert CD4 T cells away from Th17 differentiation and inflammatory IL17 or GM-CSF (114) production and toward the generation of more regulatory Th2 and Treg subsets (112)

& Lim, J.-W

The best methods for managing LSS largely depend on the patients specific symptoms, their functional limitations, and how they respond to interventions