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But others might need higher dosages to see results

In mammals, the DNMT family includes three functional proteins: DNMT1 preferentially methylates hemi-methylated DNA and is thus responsible for methylation during DNA replication (Pradhan et al., 1999), while DNMT3a and DNMT3b have an equal preference for hemi-methylated and non-methylated DNA and so have been classified as de novo methyltransferases (Okano et al., 1999)