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In multiple myeloma (MM), ATP-binding cassette sub-family B member 6 (ABCB6) has been identified as a key protein mediating ferroptosis resistance by maintaining glutathione (GSH) homeostasis and activating the PI3K/AKT signaling pathway

Let's break this down a bit further: Oxidative Stress : This refers to an imbalance between the production of free radicals (and other reactive species) and the body's ability to detoxify these harmful molecules or repair the resulting damage

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In a rat model of cerebral ischemia-induced neurological impairment, the co-administration of tissue plasminogen activator (tPA) with nanoliposomal Fasudil-Lip showed better neuroprotection, and prolonged therapeutic time window (TTW) and improved drug targeting (Fukuta et al., 2017)