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Phosphoproteome profiling of AD models highlights alterations independent of protein levels Since protein phosphorylation is known to contribute to AD pathogenesis 53,54 , we profiled the phosphoproteome in the same set of NLGF (3-, 6-, 12-, 18-month-old) mice and 5xFAD (12-month-old) and their age-matched WT controls

Peptide safety considerations remain important, but sermorelin demonstrates a favorable profile

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Trypsin (TPCK-treated, from bovine pancreas), pepsin (from porcine gastric mucosa), dithiothreitol (DTT), acetaminophen (APAP), HPLC-grade acetonitrile (ACN) and methanol (MeOH), iodoacetamide (IAM), glucose-6-phosphate dehydrogenase (type XV, from baker's yeast), and other chemicals were purchased from Sigma-Aldrich (St