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In light of the restricted treatment options for canine tumors, companion animal testing for new drugs could lead to the discovery of more effective treatments for oncology in both veterinary and human medicine

) and iv) transition-metal catalysed formation of free radicals [64, 89]

Several specific mechanisms of immune cell mitochondrial dysfunction in the perioperative period have been identified: 2.1.3.1 Warburg-like effect in innate immune cells The Warburg effect, first described by Otto Warburg in the 1920s, refers to the phenomenon wherein cancer cells preferentially metabolize glucose via aerobic glycolysis rather than oxidative phosphorylation, even in the presence of adequate oxygen (55)

[DOI] [PubMed] [Google Scholar] [25].Sharabi A, Haviv A, Zinger H