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The M6G conjugate has an enzymatic hydrolysis rate similar to that of codeine, and roughly 1/4th that of the M3G glucuronide conjugate.1 Therefore, when developing a method for the cleavage of a wide range of substrates, it is worthwhile to explore conditions that will adequately account for these variations in conjugate hydrolysis rates

Each peptide was scored using weighted criteria: Clinical Evidence (40%) based on peer-reviewed studies, Safety Profile (25%) from adverse event data, Cost-Effectiveness (20%) comparing monthly treatment costs, and Accessibility (15%) considering prescription requirements and availability through physician-supervised clinics

Notably, the LPC baseline controls in the snRNA-seq samples were saline-injected, whereas in the scRNA-seq dataset they were uninjected

Narasimhaiah D, Mahadevan A