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The integration of these applications into a cascading circular system is conceptualized in Figure 5, which illustrates the fungal biorefinery model

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It aggravates RA by inducing gut dysbiosis, disrupting the intestinal barrier, and promoting a Th17-skewed immune response, often accompanied by increased generation of citrullinated proteins ( P.g weakens the gut barrier and permits its arthritogenic actions ( P.g also exacerbates inflammatory bowel disease (IBD) by directly degrading the tight junction protein ZO-1 via its gingipains, and by altering gut microbiota to expand IL-9-producing CD4+ T cells, which drive intestinal inflammation (Tsuzuno et al., 2021