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Butt HZ, Atturu G, London NJ, Sayers RD, Bown MJ

Transient and mild stress (such as transient ischemic preconditioning) can induce moderate mitophagy to exert a protective effect, while sustained and high-intensity stress (such as long-term severe ischemia and severe oxidative stress) is prone to trigger excessive mitophagy, shifting the regulatory effect toward damage

By fighting these harmful molecules, glutathione helps maintain skin elasticity, reduce pigmentation, and promote an even skin tone

The chapter discusses the use of zebrafish models in toxicological research to investigate mitochondrial reactions to environmental stressors and xenobiotics