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While these metabolic alterations are dictated by numerous factors, including the genetic alterations in the tumour and the tumour environment or tissue of origin, recent attention has focused on the role of serine metabolism in supporting cancer cell growth 2

254 Thalidomide is an immunomodulatory glutamate derivative that significantly reduces the protein expression levels of p-AKT and p-PI3K in intestinal epithelial cells and exerts anti-inflammatory effects by suppressing the activation of the PI3K/AKT pathway

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While mechanistically enigmatic, phenylacetylglutamines robust functional validation demands urgent mechanistic dissection to assess druggability, while serving as a caution against premature clinical extrapolation from correlative findings alone