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In contrast, the mRNAs for the genes responsible for the sterol biosynthetic enzymes HMG CoA reductase and farnesyl diphosphate synthase show only a slight increase at high curcumin concentrations, which also results in reduced cell viability (113)

Anti-ATF4 (#10835-1-AP), anti-Nrf2 (#16396-1-AP), anti-DDIT4 (#10638-1-AP) and anti-ChaC1 (#15207-1-AP) antibodies were obtained from Proteintech (Wuhan, China)

Extracellular signal-regulated kinase (ERK), a MAP kinase family that modifies gene expression through the phosphorylation of a variety of transcription factors, is the most frequent pathway associated with the control of cell proliferation

Significant challenges remain in the development of effective lactate/lactylation-targeted therapies