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( Global RAS activation induces the secretion of TNF- by macrophages, T cells, renal cells of the epithelium and mesangium, and cardiac cells ( IL-1 is also involved in the pathogenesis of hypertension and hypertension-induced organ damage ( Macrophages and atherosclerosis Obesity is one of the most important predisposing factors for the development of atherosclerotic cardiovascular disease ( Obesity is characterized by a decrease in anti-inflammatory/atheroprotective adipokines and an increase in proinflammatory/atherogenic adipokines ( Atherosclerosis is a chronic inflammatory response

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Additionally, the effects of oral administration of a synthetic fragment of human growth hormone have been extensively studied to assess their potential in promoting fat loss and supporting overall metabolic function

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