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doi: 10.1016/j.cell.2013.12.010 100 YangF.SunS.-Y.WangS.GuoJ.-T.LiuX.GeN.et al

Schmidt, K., Noureen, A., Kronenberg, F., & Utermann, G

Age-related increases in oxidative stress have been associated with chronic inflammation, cardiovascular and neurodegenerative disease, osteoarthritis and type 2 diabetes in humans (Reference Cannizzo, Clement and Sahu4Reference Rains and Jain6) and companion animals, namely cats (Reference Brown7,Reference Vite and Head8) and dogs (Reference Brown7Reference Pizzirani10)

Rotenone is known to be a potent inhibitor of complex I of the mitochondrial respiratory chain in all cell types, by inhibiting the function of mitochondrial NADH dehydrogenase activity (Sherer et al ., 2003