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In particular, we focused on the p21 N-terminal cyclin-CDK binding domain, required for inhibition of G1/S cell cycle progression, and the C-terminal PCNA binding domain involved in suppressing DNA synthesis (Chen et al, 1995) (Fig 2D)

Other common symptoms may include slurred speech, trouble with rapid hand movements, shaky head movements, poor vision, difficulty standing still with eyes closed, and certain reflex changes in the feet

FeSOD-A gene amplification increases the FeSOD protein expression and enzyme activity in a induced resistance to benznidazole and gentian violet treatments [73]