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Therefore, taken together, these limitations reflect the need for developing a more accessible and simpler assay that can measure the rate of NADPH consumption by a specific pathway, such as the one mediated by glutathione-disulfide reductase (GSR)

Limit Medications and Compounds That Increase Homocysteine A number of prescription drugs and natural compounds have been shown to increase homocysteine by interfering with folate absorption, or metabolism of homocysteine, including (35-38): Cholestyramine Colestipol Fenofibrate Levadopa Metformin Methotrexate Niacin Nitrous oxide Pemetrexed Phenytoin Pyrimethamine Sulfasalazine 17

10.1111/cpr.13289 223 ZhangX.LiJ.YanM

Clinical evidence also highlights the link between L2HGDH impairment and antioxidant systems