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In a study on C57BL/6J mice, lifelong supplementation with spermidine led to a significant extension of lifespan, with improvements in mitochondrial function, reduced oxidative stress and enhanced autophagic activity (Reference Eisenberg, Knauer and Schauer22)

demonstrated that leonurine ameliorated ferroptosis in CI-AKI by activating and upregulating the expression of Nrf2[118]

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BPC-157 addresses vascular formation through the VEGFR2 pathway while TB-500 addresses cellular migration through cytoskeletal dynamics distinct pathways with minimal overlap