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As copper is a cofactor in tumor angiogenesis, and its high levels influence tumor growth [110], Cu agents potentially can be used for BRAFV600E mutation-positive malignancies treatment and tumors resistant to BRAFV600E and MEK1/2 inhibitors [111]

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10.2174/1389557519666191009152007 56 DobrzynskaM.NapieralaM.FlorekE

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Body composition changes the appropriate angle and technique, so anyone who is very lean or unsure of the tissue depth should have a clinician demonstrate it

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