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Despite promising regenerative outcomes in animal modelssuch as achieving NP cell survival rates reaching 85%, a 3.3-fold increase in COL2 synthesis, and 87% recovery of disc height through spatiotemporally controlled release, ROS scavenging, and immune modulationsignificant challenges remain for clinical translation

The very high inter-variability in GM composition creates challenges in the development of standardized microbiome-based interventions to achieve optimal efficacy in this case an individuals unique microbial profile is necessary

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modulation of these stimuli offers future therapeutic possibilities