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Description

This deficiency creates a cycle: low glutathione leads to more oxidative stress, which leads to more skin reactivity, which further depletes glutathione

First, under conditions of nutritional ketosis, -HB constitutes the principal KB in systemic circulation, representing the majority of the dynamic range in circulating ketone concentrations

12 , e2409344 (2025)

To this end, the Pmc4 mediator subunit was fused to a degron, and we found that IAA17 in combination with the two F-box proteins atAFB2 and osTIR1 was most effective (Supplementary Fig