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For decades, methotrexate has been used as a standard of care treatment for cancer patients (Newman and Maddocks, More recently, it has been established that the repression of tumor suppressor genes by methylation, which is dependent on SAM levels, is a key-initiating event for many cancers (Kulis and Esteller, De novo serine synthesis has also been identified as a metabolic vulnerability of many cancers, including non-small cell lung cancer (NSCLC), breast cancer, and melanoma (Locasale et al., Glycine metabolism has also been shown to be important in cancer development and growth

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J Nutr 134:489492 Yamaoka Y, Takimura O (1990) Manufacture of glutathione with green algae Dunaliella

Plant Physiol Biochem 48(8):663672 Chen P, Ran S, Li R, Huang Z, Qian J, Yu M, Zhou R (2014) Transcriptome de novo assembly and differentially expressed genes related to cytoplasmic male sterility in kenaf ( Hibiscus cannabinus L .)