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By reframing creatine from a sports nutrition supplement to a scalable, safe, and cost-effective component of mitochondrial medicine, this review outlines a pathway to address current diagnostic, predictive, and therapeutic deficits, ultimately supporting proactive, systems-level approaches to health maintenance and disease prevention

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Impact of ALI and dynamic culture conditions to CS exposure with the CFAX12 Next, the effects of whole cigarette smoke (CS) exposure were investigated using the CFAX12 system with human alveolar epithelial cells ( AX iAECs) cultured under airliquid interface (ALI) on-chip and tested under static and dynamic (stretch) conditions in the AX12 (Fig

Non-neurological features included congenital lactic acidosis, cardiomyopathy, hepatomegaly, kyphoscoliosis, optic atrophy, roving eye movements, strabismus, and distal renal tubular acidosis [55-58,60]