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Apolipoprotein E and Alzheimers disease

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Therapeutic strategies targeting HMGB1 may offer a novel approach in the treatment of MASLD [228, 229]

For example, IL-27-containing exosomes secreted by innate B-1a regulatory cells have demonstrated efficacy in suppressing uveitis in murine models by promoting Treg expansion and antagonizing pathogenic Th1/Th17 responses without observable adverse effects (112)