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While primarily studied for its roles in autoimmune conditions, PEPITEM influence on immune cell behavior has implications for bone healing because the inflammatory phase of fracture repair depends heavily on coordinated immune cell activity

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Looney and his team have documented that BM-MSC cells from patients with SLE or lupus model mice are a mix of senescent and healthy cells, and that treatment with FOXO4-DRI can selectively induce apoptosis in senescent cells, allowing the healthy cells to continue to grow and multiply