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It makes protocol design more important, not less

Compared with the current Cas9 nuclease-based approach, adenine base editors introduce point mutations more precisely and efficiently because of decreased off-target genome modifications and the absence of DNA cleavage

In Embodiment 19 of this disclosure are compounds of Formula I, or Embodiments 1-11, or a class thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R 2 is CH 2 -aryl

rebaudiana metabolites also improve renal tubular necrosis, protein casts, and diabetic kidney tissue damage caused by insulin dysregulation (Shivanna et al., 2013