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Silibinin has been proven to inhibit the upregulation of co-stimulatory molecules and major histocompatibility complex (MHC) class II molecules on lipopolysaccharide (LPS) stimulated mature DCs, while also suppressing the release of pro-inflammatory cytokines IL-12, IL-23, and TNF-, as well as CD4 + T cell proliferation and Th1/Th17 function, indicating strong immunosuppressive activity (112)

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El-Sawaf ES, Saleh S, Abdallah DM, Ahmed KA, El-Abhar HS (2021) Vitamin D and rosuvastatin obliterate peripheral neuropathy in a type-2 diabetes model through modulating Notch1, Wnt-10, TGF- and NRF-1 crosstalk

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