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In a High fat diet (HFD)-induced model of adipose tissue inflammation and insulin resistance using C57BL/6J mice, EC treatment markedly reduced adipose tissue macrophage infiltration, as evidenced by decreased F4/80 and NOX2 protein levels ( 3.5 Nrf2 Additionally, the Nrf2 pathway is a critical regulator of cellular redox balance, primarily functioning as a master regulator of antioxidant defense mechanism (Tossetta and Marzioni, 2022)

doi: 10.1158/1535-7163.MCT-06-0472 161 Hosseinzadeh AnvarLHosseini-AslSMohammadzadeh-VardinMSaghaM

The mouse primary splenocytes treated with mollugin also had reduced IL-4 and IL-5 production with downregulated PARP1 and PAR protein levels [66]