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the structural heterogeneity of the polysaccharides, the lack of clinical trials evaluating the safety and efficacy of the polysaccharides as a treatment for ulcerative colitis, and the large variation in how individuals respond to changes in the composition of the gastrointestinal tract microbiota

In the 5xFAD transgenic mouse model of AD, treatment with slow-release niacin (niaspan R ) increases microglia engagement with plaques, reduces plaque number and area, and promotes expression of microglial genes related to phagocytosis [10]