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Indeed, without effective vertical integration to harmonise findings across levels there is a risk that the theories and models under investigation become dissociated from the very phenomena which they attempt to explain 1

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Tap the syringe barrel to move air bubbles to the top near the needle

Expert Opin Investig Drugs 21(11):16611678 Ting KN, Dunn WR, Davies DJ, Sugden D, Delagrange P, Guardiola-Lematre B, Scalbert E, Wilson VG (1997) Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats