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ART is primarily administered orally, characterized by rapid onset of action but suffers from a short in vivo half-life (approximately 1 h) ( Dimeric artesunate phospholipid-conjugated liposomes (Di-ART-GPC), a novel derivative synthesized through the esterification of artesunate and choline glycerophosphate, exhibits low cytotoxicity with enhanced anti-inflammatory and antimalarial effects compared to ART alone ( In vitro drug release and degradation results showed that the Di-ART-GPC were stable in neutral physiological conditions but effectively degraded to release parent ART in the simulated weakly acidic microenvironment

The thickness of the blue arrows represents the concentration of xenobiotics

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