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Despite the absence of specific protocols for cirrhosis patients, sleep diaries are heralded as the gold standard for subjective sleep assessment ( Objective methods for sleep disorders assessment in cirrhosis include the polysomnography test which stands as the gold standard for diagnosing sleep disturbances, but its practicality is hindered by high costs and patient compliance challenges

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In a 2020 clinical study, adults supplementing with KSM-66 experienced significant improvements in overall sleep quality and mental alertness upon waking compared to placebo