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It is also important to point out that each study has its limitations, whether it is a small sample size which reduces the statistical power of the study (32, 36, 4851), heterogeneity of COPD patients enrolled in the studies such as grouping of subjects with different GOLD stages into one group, as in a study by Pierrou et al

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After that, the membranes were washed with TBST and detected using an ECL detection solution

Garcia-Tsao G, Bosch J, Kayali Z, Harrison SA, Abdelmalek MF, Lawitz E, Muellhaupt B (2020) Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension